HOUSTON -- The Astros had established such a comfort in the reliability of their high-leverage relievers that little could prepare them for what unfolded on Friday night against the Angels.Right-handers Luke Gregerson and Ken Giles, half of the Astros quartet of rock-solid relief pitchers (a group that also includes right-handers Chris Devenski and Will Harris) combined to cough up a three-run lead in a 10-6 loss that severely damaged the Astros playoff aspirations. Gregerson allowed a run on two hits in the eighth inning; Giles blew his fifth save by coming apart at the seams in the ninth.Giles surrendered six earned runs on three hits and three walks, inflating his ERA from 3.47 to 4.31 in the process. With eight games remaining in their season and their deficit for the second American League wild card now 21/2 games behind the Tigers, the Astros were left floored by the development involving Giles in particular.Toughest inning of the year, Astros manager A.J. Hinch said. For a lot of reasons.Added Giles: I didnt do my job. Didnt make my pitches. Thats all I can say. I just didnt do it.The Astros (81-73) have lost twice as many games to the Angels (68-86) over the first two games of this series than they did in the first 12 meetings between the teams this season. At best, they can salvage a split of the four-game set with victories on Saturday night and Sunday.Right-hander Brad Peacock (0-0, 2.86 ERA) will make his fourth start for the Astros in the third game of the series. Peacock, who has filled in admirably for injured left-hander Dallas Keuchel (left shoulder inflammation), is 3-0 with a 4.50 ERA in five career games (three starts) against the Angels. He has not pitched against Los Angeles this season.Angels right-hander Jhoulys Chacin (4-6, 5.26 ERA) will make his 33rd appearance and 21st start of the season. Chacin is 1-2 with a 4.50 ERA in five career games (four starts) against the Astros, including 0-1 with a 9.00 ERA in two games this season.Chacin, who will make his 16th start for the Angels, has toggled between the rotation and bullpen for the Angels, rejoining the rotation on Sept. 14 against the Mariners after making four appearances out of the bullpen between Aug. 27 and Sept. 10. In his last four starts for the Angels, Chacin has pitched to a 0.87 ERA.I think Jhoulys has the ability to do both, Angels manager Mike Scioscia said. Hes done very well out of our pen and recently with some adjustments that hes made hes been very effective as a starter. I think his upside is still as a major league starter and I know thats what he wants to do and I think he can be effective doing that but if not hes shown he can throw out of our bullpen.Jordan Zimmermann Jersey . Tevez, who has had conflicts with coaches in the past, has not been called up since Sabella was named coach in 2011. Argentina boasts Lionel Messi, Gonzalo Higuain, Sergio Aguero, Ezequiel Lavezzi and Angel Di Maria. James McCann Jersey . Jordan Lynch, the all-purpose Heisman Trophy finalist from Northern Illinois, failed to make it into that exclusive club. http://www.cheaptigersjerseys.com/ . While hell be dialed in to that tournament on a course he loves, you can forgive him if his eyes glance down the calendar just a bit, towards April. Jose Iglesias Jersey . President of baseball operations Larry Beinfest was fired Friday after 12 years with the Marlins. The move came as the team neared the end of its third consecutive last-place season in the NL East. Wholesale Tigers Jerseys .com) - Following a late-game loss to the reigning NBA champs, the Toronto Raptors will look to sustain their recent high-level play as they travel to Indiana to take on the Pacers.Friday, Ryen Russillo and Danny Kanell welcome ESPN NFL analyst Darren Woodson (2 p.m. ET) and 1998 Heisman Trophy winner Ricky Williams (3:30).Todays main topics:? Colin Kaepernicks protest continues? Tennessee escapes Appalachian StateText us at 73776 (msg&data rates mmay apply) or tweet us at twitter.ddddddddddddcom/RussilloShow -- well be with you from 1 p.m. to 4 p.m. ET on ESPN Radio and ESPNRadio.com. ' ' '